Journal of Regional Section of Serbian Medical Association in Zajecar
Year 2003     Volumen 28     Number 3-4
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UDK 616.61-003.4 ISSN 0350-2899, 28(2003) 3-4 p.67-70
Original paper

Characteristics of adult polycystic kidney disease in patients with the end stage renal decease on hemodialysis

Milenko Živanović, Biserka Tirmenštajn Janković
Služba za nefrologiju i hemodijalizu, Zdravstveni centar Zaječar

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited renal disease on haemodialysis (HD) with the prevalence about 3,5-10% in the USA, Europe, Japan and our country. More than one-half of those individuals with ADPKD will develop kidney failure and require dialysis and/or renal transplantation. According to the literature, the median age of patients with ADPKD who were placed on dialysis prior to 1980 was 48 yr, whereas from 1980-1989 it was 53 yr. In addition to the kidney, persons with PKD can also develop cysts in the ovary, pancreas, spleen, central nervous system and liver. Symptoms can vary greatly among individuals: early symptoms are hypertension, urinary tract infections and hematuria. There may also be discomfort or pain in the back, flank area or abdomen due to increasing cyst size and the resultant pressure. Other related problems can include proteinuria, kidney infections and stones, fatigue, diverticula of the colon, inguinal and abdominal hernias, brain and abdominal aneurysms, and cardiac valvular abnormalities. There is no specific cure for PKD. Care is aimed at slowing down cyst enlargement and multiplication. Urological procedures and surgical interventions for PKD and related complications might be needed. The main cause of death in these patients on HD was cardiovascular events. After the initiation of the use of erythropoietin for the treatment of anaemia in patients undergoing HD in 1990, a number of studies showed that there were no differences in the survival rate among HD patients with either ADPKD or other primary renal disease. This work represents clinical characteristics of ADPBB in our patients on chronic HD.
Key words: adult polycystic kidney disease, terminal kidney failure, haemodialysis
  Correspodence to:
Milenko Živanović
Požarevačka A4 II/9, 19000 Zaječar
Serbia and Montenegro
  Received: 9. IV 2003.
Accepted: 24. IV 2003.
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