Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2004     Volumen 29     Number 3
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  UDK 616.441-07:616.097 ISSN 0350-2899, 29(2004) 3 p.193-204

Clinical Significance of TSH Receptor Autoantibodies

Aleksandar Aleksić, Željka Aleksić
Nuclear Medicine, Medical Centre Zajecar



TSH receptor auto antibodies (TRAb) were recognized as a long-acting thyroid stimulator (LATS) in mouse bioassay. At least two classes of TRAb can be associated with autoimmune thyroid disorders – thyroid stimulating auto antibodies (TSAb) that cause Graves’ hyperthyroidism and thyroid stimulation-blocking auto antibodies (TSBAb). Each class of TRAb (TSAb and TSBAb) may be detected alone or in combination in Graves’ disease and Hashimoto’s thyroiditis. Bioassays have been used to measure the stimulating class of antibodies (TSAb). Conversely, radio receptor assays have been used to detect TSH binding inhibitory immunoglobulins (TBII), i.e. both classes (stimulating and blocking) of TRAb. Clinical indications for TRAb measuring are: confirmation of Graves’ pathogenesis of hyperthyroidism and diagnosis of euthyroid ophtalmopathy, prediction of response of Graves’ hyperthyroidism to therapy and probability of neonatal thyrotoxicosis or hypothyroidism.

Key words: TSH receptor autoantibody, Graves’ disease, autoimmune thyroid disease

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
  Corresponding Address:
Aleksandar Aleksić
Nikole Pašića 83A 2/2, 19000 Zaječar
e-mail: lukaal@ptt.yu
  Paper received: 10. 08. 2004.
Paper accepted: 26. 08. 2004.
Published online: 18. 09. 2004.
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