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| UDK 616.441-07:616.097 | ISSN 0350-2899, 29(2004) 3 p.193-204 | ||||||||||
Review Clinical Significance of TSH Receptor AutoantibodiesAleksandar Aleksić, Željka Aleksić |
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| Summary: TSH receptor auto antibodies (TRAb) were recognized as a long-acting thyroid stimulator (LATS) in mouse bioassay. At least two classes of TRAb can be associated with autoimmune thyroid disorders – thyroid stimulating auto antibodies (TSAb) that cause Graves’ hyperthyroidism and thyroid stimulation-blocking auto antibodies (TSBAb). Each class of TRAb (TSAb and TSBAb) may be detected alone or in combination in Graves’ disease and Hashimoto’s thyroiditis. Bioassays have been used to measure the stimulating class of antibodies (TSAb). Conversely, radio receptor assays have been used to detect TSH binding inhibitory immunoglobulins (TBII), i.e. both classes (stimulating and blocking) of TRAb. Clinical indications for TRAb measuring are: confirmation of Graves’ pathogenesis of hyperthyroidism and diagnosis of euthyroid ophtalmopathy, prediction of response of Graves’ hyperthyroidism to therapy and probability of neonatal thyrotoxicosis or hypothyroidism. Key words: TSH receptor autoantibody, Graves’ disease, autoimmune thyroid disease Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
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Corresponding Address: Aleksandar Aleksić Nikole Pašića 83A 2/2, 19000 Zaječar e-mail: lukaal@ptt.yu |
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Paper received: 10. 08. 2004. Paper accepted: 26. 08. 2004. Published online: 18. 09. 2004. |
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| Infotrend Crea(c)tive Design | Revised: 20 May 2009 | ||||||||||
