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| UDK: 616.12-008.313-085.222 | ISSN 0350-2899, 30(2005) 2 p. 57-62 | ||||||||||
| Original paper Pharmacological cardioversion of atrial fibrillation with quinidineZoran Čeperković |
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| Summary: Atrial fibrillation is the
most common cardiac arrhythmia and a significant public health problem,
especially in elderly patients. The aim of this study was to analyse the
benefit of quinidine sulfate in the conversion of atrial fibrillation to
sinus rhythm. Furthermore, the aim of this study was to determine the
correlation of the efficiency of cardioversion with quinidine in relation
with the size of left atrium on the one side and the age of examined
patients the other. The examination included 60 patients of both gender
with detected persistent atrial fibrillation that is not stopped
spontaneously and lasts endlessly until converted. The patients were
divided in 2 groups according to etiology of disease, age and size of left
atrium. After 4 weeks of treatment with anticoagulant medications and
after achieving optimal control of ventricular frequency, the patients
received oral quinidine therapy - 200 mg of quinidine tablets every 2
hours, until a full dose of 1600mg. The number of patients with beneficial
effects of conversion was different within the groups and this difference
was statistically significant (c2=3,841,
p<0,05). In the first group of patients, where the cardioversion was more
successful (86,7% with converted rhythm), the average left atrium size was
3,68 ± 0,24 cm and the average age 55,47 ± 2,94 years. In the second
group, 66,7% of patients converted atrial fibrillation to sinus rhythm. In
the same group, the average left atrium size was 4,93 ± 0,57 cm and the
average age 67,33 ± 3,91 years. Statistically there was a significant
difference between the examined groups concerning the average of measured
left atrium sizes (t = -11,004, p<0,01). In terms of statistics, there is
also considerable difference in the average age of patients (t = -13,285,
p<0,01) between the examined groups. In the patients with successful
conversion, the average size of left atrium was 4,059 ± 0,51 cm, and in
the patients with failed conversion the average size of left atrium was
5,11 ± 0,92. The relation between the efficiency of conversion of atrial
fibrillation to sinus rhythm and left atrium size is very significant (r =
-0,461, p<0,01). In the patients with successful conversion of hearth
rhythm, the average age was 59,57 ± 5,76 years and in the patients with
failed conversion the average age was 67,43 ± 7,08 years. The relation
between successful conversion of rhythm and the age of patients is very
important (r = -0.479, p<0,01). The efficiency of pharmacological
conversion of rhythm with quinidine depends to a large extent on the left
atrium size and the age of patients. Key words: atrial fibrillation, cardioversion, quinidine, left atrial size, age of patient Note:
full text in Serbian |
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Corresponding Address: Zoran Čeperković Gočka br 7, 36210 Vrnjačka Banja tel. +381 36/616-970 e-mail: hоlidey7777@ptt.yu |
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Paper received: 27. 12. 2004. Paper accepted: 08. 04. 2005. Published online: 30. 08. 2005. |
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| Infotrend Crea(c)tive Design | Revised: 20 May 2009 | ||||||||||
