Journal of Regional Section of Serbian Medical Association in Zajecar
Year 2005     Volumen 30     Number 2
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UDK: 616.12-008.313-085.222  ISSN 0350-2899, 30(2005) 2 p. 57-62
   
Original paper

Pharmacological cardioversion of atrial fibrillation with quinidine

Zoran Čeperković
Interno odeljenje, Vrnjacka Banja

 
 

 

 
  Summary: Atrial fibrillation is the most common cardiac arrhythmia and a significant public health problem, especially in elderly patients. The aim of this study was to analyse the benefit of quinidine sulfate in the conversion of atrial fibrillation to sinus rhythm. Furthermore, the aim of this study was to determine the correlation of the efficiency of cardioversion with quinidine in relation with the size of left atrium on the one side and the age of examined patients the other. The examination included 60 patients of both gender with detected persistent atrial fibrillation that is not stopped spontaneously and lasts endlessly until converted. The patients were divided in 2 groups according to etiology of disease, age and size of left atrium. After 4 weeks of treatment with anticoagulant medications and after achieving optimal control of ventricular frequency, the patients received oral quinidine therapy - 200 mg of quinidine tablets every 2 hours, until a full dose of 1600mg. The number of patients with beneficial effects of conversion was different within the groups and this difference was statistically significant (c2=3,841, p<0,05). In the first group of patients, where the cardioversion was more successful (86,7% with converted rhythm), the average left atrium size was 3,68 0,24 cm and the average age 55,47 2,94 years. In the second group, 66,7% of patients converted atrial fibrillation to sinus rhythm. In the same group, the average left atrium size was 4,93 0,57 cm and the average age 67,33 3,91 years. Statistically there was a significant difference between the examined groups concerning the average of measured left atrium sizes (t = -11,004, p<0,01). In terms of statistics, there is also considerable difference in the average age of patients (t = -13,285, p<0,01) between the examined groups. In the patients with successful conversion, the average size of left atrium was 4,059 0,51 cm, and in the patients with failed conversion the average size of left atrium was 5,11 0,92. The relation between the efficiency of conversion of atrial fibrillation to sinus rhythm and left atrium size is very significant (r = -0,461, p<0,01). In the patients with successful conversion of hearth rhythm, the average age was 59,57 5,76 years and in the patients with failed conversion the average age was 67,43 7,08 years. The relation between successful conversion of rhythm and the age of patients is very important (r = -0.479, p<0,01). The efficiency of pharmacological conversion of rhythm with quinidine depends to a large extent on the left atrium size and the age of patients.
Key words: atrial fibrillation, cardioversion, quinidine, left atrial size, age of patient

Note: full text in Serbian
Napomena: kompletan tekst rada na srpskom jeziku

 
     
  Corresponding Address:
Zoran Čeperković
Gočka br 7, 36210 Vrnjačka Banja
tel. +381 36/616-970
e-mail: hоlidey7777@ptt.yu
 
     
  Paper received: 27. 12. 2004.
Paper accepted: 08. 04. 2005.
Published online: 30. 08. 2005.
 
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