Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2011     Vol 36     No 1
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      UDK 616.23/.24-008-053.31

ISSN 0350-2899, 36(2011) br.1 p.43-47

Literature review

The role of the immune system of newborn infant in pathogenesis
of bronchopulmonary dysplasia

(Uloga imunskog sistema novorođenčeta u patogenezi bronhopulmonalne displazije)

Jelena Ivanović, Stevan Vasiljević
Institut za neonatologiju, Beograd


Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature infants. Inflammatory cascade reaction mediated by immature immune system is very important for the development of this multifactorial disease. Immunodeficiency present in pre-term newborn infants is more severe and prolonged, which increases the risk of generalized infection, as well as lung infection, when inflammatory process is initiated and the probability for development of BPD is increased. Components of innate immune system involved in the development of BPD are Toll-like receptors (TLR), that – when activated – induce transcription factors that stimulate macrophages and dendritic cells. Components of adaptive immune system important for the development of BPD are CD4+ T lymphocytes and their cytokines, whose concentration in bronchoalveolar lavage correlates with the course and the outcome of the disease. The role of bombesin-like peptide (BLP) is mentioned in the pathogenesis of BPD through BLP receptors on macrophages. The immune system of newborn infants, through the components of innate and adaptive immunity, has a significant role in the initiation and development of BPD. An early diagnosis can be made by measuring the concentration of these components in bronchoalveolar lavage and urine. The goal of making an early diagnosis is to interrupt the inflammatory process in lungs and to suppress the pathological immune response of newborn.
Key words: bronchopulmonary dysplasia, innate immune system, adaptive immune system, inflammatory process, autoimmune lung inflammation

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian

      Corresponding Address:
Jelena Ivanović
Marijane Gregoran I prolaz 2/10, 11000 Beograd
tel. 063624068
Paper received: 18.02.2011
Paper accepted: 22.02.2011
Paper Internet issues: 20.06.2011
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Journal of Regional section of Serbian medical association in Zajecar
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