Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2004     Volumen 29     Number 3
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  UDK: 615.222.06:616.44-073 ISSN 0350-2899, 29(2004) 3 p.157-163
Original paper

Velues of IN VIVO Thyroid Tests - 99mTcO4- Thyroid Scintigraphy,
TcO4- Uptake Test (TcU) and Radioiodine Uptake Test (RAIU)
in PatientsTaking Amiodarone. Attemt to Visualize Thyroid with 99mTc-MIBI

Željka Aleksić, Aleksandar Aleksić
Nuclear Medicine, Medical Centre Zajecar



Amiodarone (AMD) is potent antiarrhytmic, iodine rich drug. Patiens treated with AMD are iodine overloaded. In 42 patients treated with AMD, 20 euthyroid and 22 with subclinical or clinical amiodarone induced thyroid dysfunction (TD), we have performed one or more »in vivo« thyroid tests – 99mTcO4- static scintigraphy, 99mTcO4- uptake test (TcU) and radioiodine uptake test (RAIU). In all but two euthyroid patients thyroid was »blocked«. Remaining two had functional nodes well visualised despite of iodine overload. Amiodarone induced thyrotoxicosis (AIT) showed either preserved or increased accumulation of tracer, AIT type 1, or reduced accumulation, AIT type 2. In patient with amiodarone induced hypothyroidism (AIH) and one with subclinical hypothyroidism RAIU in 3 h was normal. In subclinicly hyperthyroid patients findings varied. In 7 patients 99mTc-MIBI thyroid scintigraphy was done. 99mTc-MIBI thyroid visualization was good only in one subclinicly hypothyroid patient. 99mTcO4- scintigraphy, 99mTcO4- uptake test (TcU) and radioiodine uptake test (RAIU) of in vivo thyroid tests were useful in differential diagnosis of two types of AIT.

Key words: amiodarone, 99mTcO4- tyroid scintigraphy, 99mTcO4- uptake test (TcU), radioiodine uptake test (RAIU), 99mTc-MIBI thyroid scintigraphy

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
  Corresponding Address:
Željka Aleksić
Zdravstveni centar Zaječar, Služba za nuklearnu medicinu
Rasadnička B.B, 19000 Zaječar,
e-mail: lukaal@ptt.yu
  Paper received: 10. 08. 2004.
Paper accepted: 26. 08. 2004.
Published online: 18. 09. 2004.
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