Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2006     Volumen 31     No 4
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UDK: 616-056.7-053.31(497.11) ISSN 0350-2899 31 (2006) 4 p. 165-170
Original paper

Incidence and prognosis of Down Syndrome in the Gynaecology and Obstetrics Clinic in Kragujevac

Olivera Laban (1), Slobodan Obradović (2)
(1) Ginekološko-akušerska klinika KC Kragujevac, (2) Pedijatrijska klinika KC Kragujevac



Down sindrom, one of the earliest described syndromes, is numeric aberration i.e. trisomia 21. The incidence ranges from 1:700 to 1:1000 regardless of geographic, national and race qualifications. Prospective and successive study of this phenomenon showed that there was a discontinuity in the incidence. It is interesting that mothers were in most cases younger than 35 (76.6%), most often women were between 20-30 years old, although the percentage was slightly higher in the group of 30-35 old women (36%). The incidence was 0,148% in period 1996-2004, and it was slightly lower (0,098%) in period 1980-1992. All neonates were mainly delivered in time, eutrophic in body mass and with high Apgar score. The majority of diagnosed anomalies were VCC (63.34%) and osteomuscular (6.67%). In one case the outcome was fatal, and other neonates were sent to the Paediatric Clinic. Only a small number of these babies were accepted by their parents, so as much as 73.3% of them were housed in specialised centres. We are therefore of opinion that, no matter how old a pregnant woman is, antenatal screening of maternal serum markers together with ultrasonographic screening should be applied as first risk orientation.
Key words: Down syndrome, trisomia 21, human genetics, congenital anomalies.

: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian


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  Corresponding Address:
Olivera Laban,
Lepenički bulevar 1-1/8, 34000 Kragujevac
Tel 034 363266, mob 063626808
e-mail :

Paper received: 27.07.2006.
Paper accepted: 27.08.2006.
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