Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2006     Volumen 31     No 4
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UDK: 616-056.7-053.31(497.11) ISSN 0350-2899 31 (2006) 4 p. 165-170
   
Original paper

Incidence and prognosis of Down Syndrome in the Gynaecology and Obstetrics Clinic in Kragujevac

Olivera Laban (1), Slobodan Obradović (2)
(1) Ginekološko-akušerska klinika KC Kragujevac, (2) Pedijatrijska klinika KC Kragujevac

  
 

 

  
  Summary:
Down sindrom, one of the earliest described syndromes, is numeric aberration i.e. trisomia 21. The incidence ranges from 1:700 to 1:1000 regardless of geographic, national and race qualifications. Prospective and successive study of this phenomenon showed that there was a discontinuity in the incidence. It is interesting that mothers were in most cases younger than 35 (76.6%), most often women were between 20-30 years old, although the percentage was slightly higher in the group of 30-35 old women (36%). The incidence was 0,148% in period 1996-2004, and it was slightly lower (0,098%) in period 1980-1992. All neonates were mainly delivered in time, eutrophic in body mass and with high Apgar score. The majority of diagnosed anomalies were VCC (63.34%) and osteomuscular (6.67%). In one case the outcome was fatal, and other neonates were sent to the Paediatric Clinic. Only a small number of these babies were accepted by their parents, so as much as 73.3% of them were housed in specialised centres. We are therefore of opinion that, no matter how old a pregnant woman is, antenatal screening of maternal serum markers together with ultrasonographic screening should be applied as first risk orientation.
Key words: Down syndrome, trisomia 21, human genetics, congenital anomalies.

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
 		  
 

REFERENCES

  1. Zergollern Ljiljana.i suradnici, Humana Geneti¬ka,Medicinska Nknada Zagreb,1994::452-468
  2. Feneroff A. et Martin R..Neonatal-Perinatal Medicine,VII izdanje,2002:488-509
  3. Zergollern Ljiljana, Pedijatarija, Medicinska naknada, Zagreb, 1994 : 82-5
  4. Vejnović Tihomir., Neinvazivni ultrazvučni skrining fetal¬nih anomalija, Jugoslovenska pedijatrijska škola, Petrovac na moru 31.05.- 07.06.1998 : 227-8
  5. Papić Feodora, Genetsko savetovanje, Jugoslovenska pedijatrijska škola, Petrovac na
  6. Moru 31.05.- 07.06.1998::214 - 7
  7. Resta R.G. and collegues, Implicationa for prenatal screening and genetic counseling,Am.J.Med.Genetics Part A,2005, 133A(1) 31-6
  8. Haddow,JE,Pamaki,GE et al,Reducing the need for amniocentesisin women 35 years of age or older with se¬rum markers for sceening N.Eng.J Med 1994,330:1114
  9. Wald.JJ.Kennard,A Heckshaw,A, Antenatal screening for Down Syndrome J Med Screen 1997,4:181
  10. Hook EB .Down syndrom and risk factors, JAMA 1983, 249: 2034-2038,
  11. www.nas.com/downsyn/benke.html Benke J Paul,MD.Risk and recurrence risk of Down Syndrome, University of Miami School of Medical Miami, FLA, Pediatric Genetics 1995:
  12. National Center on Birth Defects and Development Disabilities, Risk factors for Down Syndrome: Maternal cigarette smoking and oral contraceptive Use in Population – based case-control study, Bearth defect research (Part A)67: 617-624,2003
  13. Jovanović B.,Arsenijević B.,Udeo kongenitalnih poremeća¬ja morfogeneze u patologiji novorođenih u porodilištu KBC-Kragujevac od 1980 do 1992g, Acta medica Medianae br3, 1996,37-41,
  14. Geneva foundation for medical education and research, SBU Alert-Maternal serum screening for Down Syndrome, Swedish Council on Tehnology Assessment in Health care, Eur J Hum Genet 1996;4(2):113- 9
  15. Wald NJ.Rodeck. C,Hckshaw AK, Walters J at al First and second trimester antenatal screening for Down syndrome:screening studuy SURUSS Health TechnAss2003:7(11)
  16. Children Hospital Boston and Harvard Medical School, Physitions must Improve How they deliver a prenatal diagnosis of Down Syndroma, 7 specific Recomendation Offered, Prevention Strategies for Healthy Babies and Healthy Children: Hearing Before the Select. Boston 2005.:59
  17. www.ndss.org/Down Syndrome Society , Advanced maternal age pragnancies call for changes in screening strategies, 2005
  
  Corresponding Address:
Olivera Laban,
Lepenički bulevar 1-1/8, 34000 Kragujevac
Tel 034 363266, mob 063626808
e-mail : oljalaban@microsky.net

Paper received: 27.07.2006.
Paper accepted: 27.08.2006.		  
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