Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2006     Volumen 31     Number 1-2
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UDK 616.98:578.825-053.31 ISBN 0350-2899, 31(2006) 1-2 p 23-30
   
Review

Neonatal Herpes Simplex Virus Infection - Modern management

Adnan Bajraktarević (1), Aida Đulepa-Đurđević (2), Lutvo Sporišević (3), Hakam Khatib (4)
(1) Javna ustanova Kantona Sarajevo, Dom zdravlja, Centar Vrazova, Odjel za predškolsku djecu, (2) Opća bolnica Sarajevo, (3) Hitna pomoć Sarajevo - Odjel za djecu, (4) Klinički medicinski centar Univerziteta Sarajevo, Perinatološko-neonatološki odjel

  
 

 

  
  Summary:
Neonatal herpes simplex virus (HSV) infections are transmitted from an infected mother, usually vertically, during delivery. Newborns can develop herpesvirus infections through contact with infected secretions in the birth canal. The incidence of infection is approximately one per 3,000 to 20,000 live births. Neonatal herpes simplex virus infections can result in serious morbidity and mortality. The diagnosis of neonatal HSV can be difficult, but it should be suspected in any newborn with irritability, lethargy, fever or poor feeding at one week of age. Diagnosis is made by culturing the blood, cerebrospinal fluid, urine and fluid from eyes, nose and mucous membranes. A neonatal HSV infection can be devastating to an infant. Most of these infections are caused by HSV-2, but 15 to 30 percent are found to be caused by herpes simplex virus type 1 (HSV-1). All infants suspected to have or who are diagnosed with an HSV infection should be treated with parenteral antiviral therapy. The duration of disease before antiviral therapy is initiated is significantly correlated with morbidity and mortality. All HSV-exposed neonates should be monitored closely for any signs of infection, and cultures for HSV-1 and HSV-2 should be obtained quickly. 
Key words: Hepesvirus, infection, infants-newborns, morbidity, mortality

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian

  
     
  Corresponding Address:
Adnan Bajraktarević
Husrefa Redžića 13/7, 71000 Sarajevo, Bosna i Hercegovina
Mob: 0038761/199-526
Fax: 0038733/555-391
e-mail: bajrakm@bih.net.ba

Paper received: 14.06.2006.
Paper accepted: 10.08.2006.
Published online: 22.09.2006.		  
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