Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2007     Volumen 32     Number 2-3
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UDK 616.441-008.61 ISSN 0350-2899, 32(2007) br.2-3 p.117-123

Clinical Manifestations of Thyrotoxicosis - Literature Review

Aleksandar Aleksić (1), Željka Aleksić (1), Vladimir Mitov (2), Miljan Jović (3)
(1) Služba za nuklearnu medicinu, Zdravstveni centar Zaječar
(2) Internistička služba, Zdravstveni centar Zaječar
(3) Služba hitne medicinske pomoći, Zdravstveni centar Zaječar



This article presents a review of symptoms and signs of thyrotoxicosis and their prevalence among patients, as well as specific symptoms and signs depending on the etiology of thyrotoxicosis, according to relevant literature (literature review). The most common symptoms in patients suffering from thyrotoxicosis are weight loss despite normal or increased appetite, palpitation, fatigue, muscular weakness, nervousness, anxiety, annoyance, increased sweating, heat intolerance, dyspnea and insomnia. Some patients report swelling of legs and hyperdefecation. A small percentage of patients have symptoms like the loss of appetite, constipation or even weight gain. As regards clinical signs in thyrotoxic patients, they are tachycardia (sinus tachycardia, less often fibrilloflatter or extrasystolic arrhythmia) in almost all patients, fine hand tremor, warm, moist and fine skin, divergent hypertension, strong and rapid pulse rate (pulsus altus et celer), and in some patients visible pulsation of carotid arteries. Symptoms may appear suddenly, or gradually but with a rather subtle character over a longer period of time. Except those common manifestations of hypermetabolism, there are also specific signs of illness which depend on the etiology of thyrotoxicosis.
Key words: thyrotoxicosis, symptoms of disease, signs of disease

: kompletan tekst na srpskom jeziku
Note: full text in Serbian
  Corresponding Address:
Aleksandar Aleksić
Zdravstveni centar Zaječar
Rasadnička bb, 19000 Zaječar
e-mail adresa: lukaal@ptt.yu

Paper received: 25.7.2007.
Paper accepted: 19.8.2007.
Published online: 19.10.2007.
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