Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2012     Vol 37     No 4
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      UDK 618.3:616.12-008.331.1 ; 618.3-074:577.1

ISSN 035-2899, 37(2012) br.4 p.233-238

Original paper

Importance of early detection of uric acid, creatinine and urea in serum and amniotic fluid in preeclampsia
Značaj ranog određivanja mokraćne kiseline, kreatinina i uree u serumu i plodovoj vodi
u preeklampsiji

Ana Jakovljević (1), Mirjana Bogavac (2), Aleksandra Nikolić (2), Jan Suđi (3)
(1) Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Klinički centar Vojvodine, Centar za laboratorisku medicinu, (2) Univerzitet u Novom Sadu, Medicinski fakultet Novi Sad, Klinika za ginekologiju i akušerstvo, Klinički centar Vojvodine, (3) Zavod za zdravstvenu zaštitu radnika Novi Sad



Introduction: Preeclampsia is a severe form of hypertension caused by pregnancy. It can happen in 6 to 8% of all pregnancies. The first trigger is considered to be the inadequate supply of placenta with blood, which eventually leads to releasing various mediators that damage endothelium and cause changes of metabolism and inflammation. The Aim of this study was to evaluate the levels of uric acid, urea and creatinine in serum and amniotic fluid in pregnant women with preeclampsia in comparison to healthy pregnant women, in order to determine the importance of these markers in pregnancy so as to ensure early detection and the possibility of preventing this disorder. Material and methods: The study included 59 pregnant women divided in two groups: the experimental group of 11 pregnant women with preeclampsia occurring after 20th week of pregnancy and the control group with 48 healthy pregnant women. In both groups, blood samples were taken between 16th and 19th week of pregnancy and amniocentesis indicated by geneticists was performed; in blood samples and amnionic fluid uric acid, urea and creatinine were determined by colorimetric methods. Results: The levels of uric acid in amniotic fluid were statistically significantly higher in pregnant women with preeclampsia comparing to the control group, the levels of urea and creatinine in serum were higher in the experimental group, and the levels of urea in serum were similar in both groups. Conclusion: The results of the study show the importance of uric acid in the pathogenesis of preeclampsia and the possibility of using uric acid as a biochemical marker in the early screening of pregnant women in risk of preeclampsia.
Key words: preeclampsia, amniotic fluid, uric acid, creatinine, urea

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
      Corresponding Address:
Ana Jakovljević
Univerzitet u Novom Sadu,
Medicinski fakultet Novi Sad,
Klinički centar Vojvodine,
Centar za laboratorijsku medicinu,
Hajduk-Veljkova 3.
Paper received: 10. 12 . 2012
Paper accepted: 12. 12. 2012
Paper Internet issues: 8.3.2013.
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Timočki medicinski glasnik, Zdravstveni centar Zaječar
Journal of Regional section of Serbian medical association in Zajecar
Rasadnička bb, 19000 Zaječar, Srbija

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