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| UDK 617.7:616.441-008.61-085 |
ISSN 035-2899, 38(2013) br.3 p.133-141 |
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Review article Predictors of thyrosupressive drug therapy outcome in patients with Graves' disease (Prediktori ishoda medikamentne tirosupresivne terapije kod pacijenata sa Grejvsovom bolešću)
Aleksandar Aleksić (1), Željka Aleksić (2), Saška Manić (3),
Vladimir Mitov (1), |
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| Download in pdf format | Summary: Graves' disease (GD) is the most common cause of hyperthyroidism caused by circulating IgG antibodies that activate the TSH receptor (TRAb). Thyrosupressive drug therapy (TDT) is the initial treatment for GB, especially in younger patients, and is the first treatment of choice in Europe. Upon discontinuation of TDT, recurrence of disease is usually manifested during the 6 months after cessation of therapy, but can be observed even after several years. The overall rate of recurrence in patients treated by TDT is usually 30-50%. In patients who develop recurrence after cessation of medicament therapy one should consider referral to surgical treatment, or therapy with radioactive iodine. In previous decades, numerous studies intensively searched for factors that could predict the outcome of TDT. They studied the individual or the joint effects of gender, age, size of goite, ophthalmopathy, thyroid hormone levels, TRAb and other immunological, biochemical and clinical parameters as potential predictors of TDT outcome. The importance of determining possible clinical and biochemical parameters of thyroid status of patients with GB, from which one can predict the outcome of TDT, is in the possibility that, according to the findings, some of other forms of treatment such as radioiodine therapy or surgical treatment could be chosen in due time. The results of most studies show that each parameter of thyroid status at diagnosis is not a sufficient predictor of the outcome; a combination of parameters provides a better prediction of outcomes, but there is no consensus on early prognostic parameters that would indicate the likelihood of long-term stable remission of GB after TDT. Key words: Graves' disease, throyupressive drug therapy, outcome, predictive factors Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
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Corresponding Address: Aleksandar Aleksić, Nikole Pašića 83A 2/2, 19 000 Zajecar, Srbija; E-mail: lukaal@ptt.rs |
Paper received: 1.10. 2013 Paper accepted: 7.11. 2013 Paper Internet issues: 30.12.2013 |
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