|
||||||||||||||||||||||||||||||||||||
| [
Contents
] [ INDEX ]
|
||||||||||||||||||||||||||||||||||||
| UDK 616.441-008.61-085.357 |
ISSN 035-2899, 38(2013) br.4 p.162-169 |
|||||||||||||||||||||||||||||||||||
|
Original paper Clinical parameters as predictors of thyroid-suppressive drug therapy outcome in Graves disease patients (Klinički parametri kao prediktori ishoda medikamentne tiropsupresivne terapije kod pacijenata sa Grejvsovom bolešću) Aleksandar Aleksić (1), Željka Aleksić (2), Saška
Manić (3), Vladimir Mitov (1), |
||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||||
| Download in pdf format | Summary: Graves' disease (GD) is an organ specific autoimmune disease, characterized by hyperthyroidism with the presence of diffuse goiter and the extrathyroid manifestations, such as a thyroid ophthalmopathy. Thyrosupressive drug therapy is the initial therapy for GD. Upon cessation of drug therapy, recurrence of disease is usually manifested during the 6 months after discontinuation of therapy in some patients. There is continuous lasting efforts to identify factors that may indicate the likelihood of achieving remission, or relapse after cessation of drug therapy, which could facilitate the timely decision for ablative therapy. The aim of our study was to determine the significance of simple clinical parameters such as gendre, age, family history of thyroid disease, the presence and severity of ophthalmopathy, and the severity of the clinical picture of the disease as predictors of remission during tirosupressive drug therapy. The study was conducted in a prospective manner in 106 consecutive patients with newly diagnosed GD, 21 males (19.81 %) and 85 females (18.19 %), in which thyrosupressive drug therapy was started and clinical data of interest were collected. The average age of men was 50.47 years and women 42.74 years. After the follow-up period of 12 months, patients were divided into two groups according to the response to thyropsupressive drug therapy: group A - patients who achieved remission and group B - patients who did not achieve remission. There was no statistically significant difference between the gender on the outcome of the therapy (χ2=1.275, p = 0.259) . Also , there was no statistically significant difference in the age of the patients who entered remission and those who did not (t=-0731, p=0.467). There was no statistically significant difference between patients with a positive family history and those with a negative family history according to the outcome of the therapy (χ2=0.526, p=0.468). There was no statistically significant difference in outcome between treatment groups with different severity of the clinical picture at the beginning of the disease (Z =-0383, p=0.702 Mann -Whitney U test) . There were no significant differences between patients in remission and non-responders according to the level of FT4 and FT3 at the beginning of the disease (p=0.405 and p=0.404 respectively) . There was no statistically significant difference between non-responders and patients in remission according to the presence and severity of ophthalmopathy at the onset of illness (χ2=0.482, p=0.487) . We conclude that simple clinical parameters determined at the beginning of the disease , such as gender, age, family history, clinical picture and the presence and severity of ophthalmopathy, have no significance as predictors of outcome of thyrosupressive drug therapy. Keywords: Graves‘ disease, thyrosupressive drug therapy, remission, predictive factors Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
|||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||||
|
Corresponding Address: Aleksandar Aleksić, Nikole Pašića 83A 2/2, 19000 Zajecar, Serbia; E-mail: lukaal@ptt.rs |
Paper received: 5.11.2013 Paper accepted: 3.12.2013 Paper Internet issues: 14.3.2013 |
|||||||||||||||||||||||||||||||||||
| [
Contents
] [ INDEX ]
|
||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||
