Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2014     Vol 39     No 3
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      UDK 618.3:616.379-008.64-071

ISSN 035-2899, 39(2014) br.3 p.102-105

Original paper

Screening of gestational diabetes by O′Sullivan test
Skrining gestacijskog dijabetesa O′Sullivan testom

Milosava Đelkapić, Božidar Nešević
Dom zdravlja Užice



  Download in pdf format   Extended summary:
Gestational diabetes (GD) is any degree of disorder of glucoses tolerance which is first discovered in pregnancy. According to the recommendation of Study group of the World Health Organisation it is determined as a special kind of diabetes in 1985. Today the prevalence of GD is significantly different in examined population and is between 1% and 14%, and is also different in regions among races. Pregnant women with diabetes are more often with eclampsia, polyhydramnios and Caesarean section, and their foetuses have bigger risk of perinatal morbidity et mortality, macrosomia with partial traumas, neonatal hypoglycaemia and hypobilirubinemia. It′s raised perinatal mortality and pregnancy of partial anomalies. For that reason more attention is directed to early diagnostic of diabetes mellitus. The aim of our study was to evaluate the significance of the use of glucose challenge test (GCT-O′ Sullivan test) with 50 g glucose, in identifying pregnant women with GD. The research included 234 pregnant women in 24-28 weeks of gestation, divided in two groups according to age. There were 207 pregnant women aged 35 in the first group and 27 pregnant women aged 36 and more in the second group. Glycaemia hexokinase was determined by enzyme method on a Dimension RxL Max biochemical analyzer by reagents of the Siemens Company. The average value of morning glycaemia in the first group was 4.64±0.56 mmol/L, and in the second group it was 4.97±1.17 mmol/L, which was statistically a significant difference (t=2.44; p<0.05). GD was found by morning glycaemia at 11.6% pregnant women in I group and at 14.8% pregnant women in II group. The average of glycaemia one hour after GCT was 6.03±1.47 mmol/L in I group and 6.79±1.94mmol/L in II group, which was also a significant difference statistically (t=2.10; p<0.05). Based on the GCT, GD was detected in 3.9% in I group and in 10% in II group. Diagnostic oral glucose tolerance test was indicated in 14% of pregnant women in I group and in 25% in II group. In our research we identified pregnant women with GD and also showed the importance of performing GCT by means of which a certain number of GD pregnant women can be identified, which otherwise cannot be discovered by morning glycaemia.
Key words: gestational diabetes, hyperglycaemia, macrosomia, pregnancy

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
      Corresponding Address:
Milosava Đelkapić,
Užičke republike 42/3, 31000 Užice, Srbija;
Paper received: 7.4.2014
Paper accepted: 16.7.2014
Paper Internet issues: 26.9.2014
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Timočki medicinski glasnik, Zdravstveni centar Zaječar
Journal of Regional section of Serbian medical association in Zajecar
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