Journal of Regional Section of Serbian Medical Association in Zajecar
Year 2004     Volumen 29     Number 2
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UDK 616.42-006.44 ISSN 0350-2899, 29(2004) 2 p.83-89

Features of Low Grade B-cell non Hodgin Lymphomas

Darko Vugdelija
Internistička služba, Zdravstveni centar Zaječar



  Summary: Understanding of lymphoma histogenesis can be achieved by elucidating specific cell line from which malignant clonal proliferation originates. First we have to determine cell differentiation and lineage fidelity. Comparing it with maturation level of normal lymphocyte counterparts, we can find out et which moment clonal transformation has taken place. Four major mechanisms are involved in lymphoma pathogenesis: gen transformations of lymphoma clone; tumour infection by oncogen viruses; antigen stimulation and selection of tumour cells and host immunodeficiency. This review presents contemporary understanding of lymphoma histogenesis and pathogenesis, and compares morphology, immunogenetics and clinical features of most frequent low grade B-cell NHL.
Key words: NHL, hystogenesis, pathogenesis

Note: full text in Serbian
Napomena: kompletan tekst rada na srpskom jeziku

  Corresponding Address:
Darko Vugdelija
Naselje Kraljevica B-1 I/16, 19000 Zaječar
tel: 019/430041 i 064/1699782
e-mail: vugdelija@ptt.yu
  Paper received: 18. 01. 2004
Paper accepted: 04. 03. 2004
Published online: 05. 08. 2004
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