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| UDK 616.61-06:616.122 |
ISSN 035-2899, 38(2013) br.4 p.174-180 |
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Original paper Left ventricular hypertrophy in predialysis chronic kidney disease patients: prevalence and risk factors (Hipertrofija leve komore kod bolesnika u predijaliznom periodu hronične bubrežne bolesti: zastupljenost i faktori rizika) Biserka Tirmenštajn
Janković(1), Dušan Bastać(2), Sanja Milošević(3), Svetlana Žikić(1),
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| Download in pdf format | Summary: Left ventricular hypertrophy (LVH) is a powerful independent predictor of mortality in patients with chronic kidney disease (CKD), but few studies are available before the start of dialysis treatment. The aim of our study is to evaluate the prevalence and clinical correlates of LVH in asymptomatic CKD patients, not yet undergoing renal replacement therapy. We carried out a crosssection study with 31 CKD patients (16 males, mean age 66.0±10.6 years, CrCl 16.5±5.5) and 21 healthy controls (11 males, mean age 65.1±9.0 years). Left ventricular mass (LVM) was calculated using the method of Devereux and Reichek. LVH was defined as left ventricular mass index (LVMI) greater than 131 g/m² in men and greater than 100 g/m² in women. In comparison to controls, patients with CKD had significantly higher left ventricular mass index (LVMI: 177.9±40.6 vs 129.5±24.6; p=0.000) and higher prevalence of LVH (LVH: 96.8% vs 71.4%; p=0.013, eccentric in 63.3%). Multivariate regression analysis showed that proteinuria, haemoglobin and serum creatinine were the only independent risk factors for LVMI (model R2=0.633). The high prevalence of LVH in predialysis population indicates that a thorough cardiovascular evaluation is necessary regardless of the absence of symptoms, and that prevention should begin in the early stages of CKD, acting on known cardiovascular risk factors. Key words: Left ventricular hypertrophy, echocardiography, chronic kidney disease Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
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Corresponding Address: Mirjana A. Janićijević-Petrović, Klinika za oftalmologiju; Klinički centar Kragujevac; Ul. Zmaj Jovina 30; 34000 Kragujevac; Srbija; E-mail: mira.andreja@yahoo.com |
Paper received: 6.12.2013 Paper accepted: 10.12.2013 Paper Internet issues: 14.3.2013 |
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