Journal of Regional Section of Serbian Medical Association in Zajecar

Year 2013     Vol 38     No 4
     
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      UDK 616.61-06:616.122

ISSN 035-2899, 38(2013) br.4 p.174-180

     
   
Original paper

Left ventricular hypertrophy in predialysis chronic kidney disease patients:
prevalence and risk factors

(Hipertrofija leve komore kod bolesnika u predijaliznom periodu hronične bubrežne bolesti:
zastupljenost i faktori rizika)

Biserka Tirmenštajn Janković(1), Dušan Bastać(2), Sanja Milošević(3), Svetlana Žikić(1),
Milenko Živanović(1)


(1) ZDRAVSTVENI CENTAR ZAJEČAR, SLUŽBA NEFROLOGIJE I HEMODIJALIZE,
(2) PRIVATNA INTERNISTIČKA ORDINACIJA "DR BASTAĆ",
(3) ZDRAVSTVENI CENTAR ZAJEČAR, SLUŽBA ZA LABORATORIJSKU DIJAGNOSTIKU

     
 
 
     
 

 

         
  Download in pdf format   Summary:
Left ventricular hypertrophy (LVH) is a powerful independent predictor of mortality in patients with chronic kidney disease (CKD), but few studies are available before the start of dialysis treatment. The aim of our study is to evaluate the prevalence and clinical correlates of LVH in asymptomatic CKD patients, not yet undergoing renal replacement therapy. We carried out a crosssection study with 31 CKD patients (16 males, mean age 66.0±10.6 years, CrCl 16.5±5.5) and 21 healthy controls (11 males, mean age 65.1±9.0 years). Left ventricular mass (LVM) was calculated using the method of Devereux and Reichek. LVH was defined as left ventricular mass index (LVMI) greater than 131 g/m² in men and greater than 100 g/m² in women. In comparison to controls, patients with CKD had significantly higher left ventricular mass index (LVMI: 177.9±40.6 vs 129.5±24.6; p=0.000) and higher prevalence of LVH (LVH: 96.8% vs 71.4%; p=0.013, eccentric in 63.3%). Multivariate regression analysis showed that proteinuria, haemoglobin and serum creatinine were the only independent risk factors for LVMI (model R2=0.633). The high prevalence of LVH in predialysis population indicates that a thorough cardiovascular evaluation is necessary regardless of the absence of symptoms, and that prevention should begin in the early stages of CKD, acting on known cardiovascular risk factors.
Key words: Left ventricular hypertrophy, echocardiography, chronic kidney disease

Napomena: kompletan tekst rada na srpskom jeziku
Note: full text in Serbian
     
             
     
     
      Corresponding Address:
Mirjana A. Janićijević-Petrović,
Klinika za oftalmologiju; Klinički centar Kragujevac; Ul. Zmaj Jovina 30; 34000 Kragujevac; Srbija;
E-mail: mira.andreja@yahoo.com
Paper received: 6.12.2013
Paper accepted: 10.12.2013
Paper Internet issues: 14.3.2013
     
             
             
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Timočki medicinski glasnik, Zdravstveni centar Zaječar
Journal of Regional section of Serbian medical association in Zajecar
Rasadnička bb, 19000 Zaječar, Srbija
E-mail: tmglasnik@gmail.com

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