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| UDK 616.61-036.1-06 ; 616.126.3 |
ISSN 035-2899, 39(2014) br.1 p.5-13 |
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Original paper Cardiac valve calcification in predialysis chronic kidney disease patients: prevalence and risk factors (Kalcifikacija srčanih valvula kod bolesnika u predijaliznom periodu hronične bubrežne bolesti: prevalenca i faktori rizika)
Biserka Tirmenštajn Janković(1), Dušan Bastać(2), Sanja
Miloševi(3), Svetlana Žikić(1), Milenko Živanović (1) |
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| Download in pdf format | Summary: Valvular calcification is a common finding in patients with end-stage chronic kidney disease (CKD) and associated with increased all-cause and cardiovascular mortality. The aim of the study was to determine the prevalence and risk factors associated with cardiac valve calcification in patients with stage IV and V CKD, not yet on dialysis. The study enrolled 61 CKD patients (34 M, mean age 62.6±13.6 years) and 22 age- and sex-matched healthy controls. All participants underwent a clinical assessment, laboratory analyses, echocardiography and carotid artery ultrasound. Calcification of the aortic and mitral valve was more frequently in patients with CKD stages IV-V than the healthy controls (47.5% : 9.1%, p=0.001). CKD patients were divided according to the presence of valvular calcification in 2 groups: group A with calcification (n=29) and group B without calcification (n=32). Patients from group A were significantly older (p<0.01), had lower creatinine clearance (p<0.01), and higher levels of P (p <0.05), CaxP product (p<0.05) and PTH (p<0.05) compared to patients from group B. Echocardiography showed a higher prevalence of left ventricular hypertrophy (LVH, p<0.01) in group A compared with group B. In patients of group A, carotid intima-media thickness (IMT) was higher (p<0.001) and calcified plaques were more frequent (p=0.005) than those in group B. Valvular calcification is highly prevalent in the predialysis period of CKD and is associated with disorders of mineral metabolism, left ventricular hypertrophy and vascular calcification. Key words: valvular calcification, chronic kidney disease, risk factors Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
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Corresponding Address: Biserka Tirmenštajn-Janković Služba nefrologije i hemodijalize, ZC Zaječar; Rasanička bb; 19000 Zajecar, Srbija; E-mail: biserkatirmenstajn@gmail.com |
Paper received: 24.12.2013 Paper accepted: 24.1.2014 Paper Internet issues: 20.6.2014 |
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