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| UDK 616.441-006.6-08 |
ISSN 035-2899, 39(2014) br.4 p.176-183 |
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Original paper The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma (Značaj određivanja stimulisanog tireoglobulina u lečenju pacijenta sa diferentovanim tireoidnim karcinomom) Marina Vlajković (1), Milena Rajić (1), Slobodan Ilić (1), Miloš Stević (1), Mila Zečević (1), Aleksandar Karanikolić (2), Radan Džodić (3), Milovan Matović (4), Vera Artiko (5) (1) Centar za nuklearnu medicinu, Klinički centar Niš, (2) Klinika za opštu hirurgiju, Klinički centar Niš, (3) Institut za onkologiju i radiologiju Srbije, KC Srbije, (4) Centar za nuklearnu medicinu, Klinički centar Kragujevac, (5) Centar za nuklearnu medicine, KC Srbije |
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| Download in pdf format | Extended summary:
Aim: The aim of this study was to evaluate the value of stimulated
tireoglobulin (sTg) in patients with differentiated thyroid
carcinoma (DTC) after the surgery and during the follow up period
comparing the findings with the diagnostic 131I-whole body scan (DxWBS),
posttherapy 131I- scan (TxWBS) and clinical findings. Patients and
methods: A retrospective review comprised 164 DxWBS of 93 patients
of whom 40 patients had only postsurgical scan while in others
control DxWBSs were included as well. Scan results were considered
positive if any focal uptake in the neck or elsewhere was visible
and negative if the physiological radioiodine accumulation
persisted. Stimulated Tg is considered positive if higher than
2ng/ml. Results: Negative value of sTg was detected in 56 cases with
negative DxWBS scan results and positive sTg was concordant with
higher values of sTg in 78 cases. Overall concordant findings were
detected in 82% of cases. Discordant findings were detected in 30
cases (18%) of which in 20 (12%) DxWBS scan was positive, while in
10 (6%) cases DxWBS scan was negative and sTg positive. All the
patients with discordant findings received radioidine
ablation/therapy. Posttherapy whole body scan was concordant with
the results of DxWBS in 20 patients with positive DxWBS and negative
sTG and in 3 patients with negative DxWBS and positive sTG. However,
negative TxWBS scan result was found in 7 of 10 patients with
negative DxWBS and positive sTg. Conclusion: Our results showed that
stimulated Tg cannot safely be used as a single marker for
assessment of residual and recurrent disease in some patients with
DTC. The results suggest that both DxWBS and sTg are of immense
importance in a diagnostic algorithm in patients with DTC during
different treatment phases. Key words: whole body scan, thyreoglobulin, differentiated thyroid carcinoma Napomena: kompletan tekst rada na srpskom jeziku Note: full text in Serbian |
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Corresponding Address: Marina Vlajković, Centar za nuklearnu medicinu, Klinički Centar Niš, Bul. dr Zorana Đinđića 48; 18 000 Niš, Srbija |
Paper received: 31.7.2014 Paper accepted: 1.8.2014 Paper Internet issues: 17.11.2014 |
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